Klaus T Wanner Selected Research

MB327

1/2023	A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment.
1/2019	New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
9/2018	Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
1/2018	Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

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Klaus T Wanner Research Topics

Disease

6	Organophosphate Poisoning 02/2024 - 01/2018
5	Epilepsy (Aura) 10/2021 - 06/2013
4	Nervous System Diseases (Neurological Disorders) 10/2021 - 01/2019
3	Poisoning 05/2024 - 09/2018
3	Respiratory Insufficiency (Respiratory Failure) 01/2024 - 09/2018
3	Neuralgia (Stump Neuralgia) 10/2021 - 02/2020
2	Respiratory Paralysis 02/2024 - 01/2023
2	Pain (Aches) 10/2021 - 01/2012
2	Seizures (Absence Seizure) 01/2017 - 08/2014
1	Amnesia (Dissociative Amnesia) 12/2023
1	Alzheimer Disease (Alzheimer's Disease) 12/2023
1	Paralysis (Palsy) 09/2018
1	Acute Pain 01/2012
1	Psychotic Disorders (Schizoaffective Disorder) 01/2012
1	Sleep Wake Disorders 01/2012
1	Substance-Related Disorders (Drug Abuse) 01/2012
1	Chronic Pain 01/2012

Drug/Important Bio-Agent (IBA)

7	GABA Plasma Membrane Transport ProteinsIBA 12/2023 - 08/2014
5	Organophosphorus CompoundsIBA 05/2024 - 09/2018
5	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 02/2024 - 09/2018
4	Cholinergic Agents (Cholinergics)IBA 05/2024 - 09/2018
4	OximesIBA 01/2023 - 02/2015
4	MB327IBA 01/2023 - 01/2018
3	Acetylcholine (Acetylcholine Chloride)FDA Link 05/2024 - 09/2018
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2021 - 01/2019
3	gamma-Aminobutyric Acid (GABA)IBA 02/2020 - 01/2012
2	AcetylcholinesteraseIBA 05/2024 - 01/2019
2	SaltsIBA 02/2024 - 01/2018
2	Atropine FDA LinkGeneric 01/2023 - 09/2018
2	Anticonvulsants (Antiepileptic Drugs)IBA 10/2021 - 01/2012
2	Formaldehyde (Formol)FDA Link 10/2021 - 01/2012
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 02/2020
2	nipecotic acidIBA 11/2020 - 06/2013
2	Analgesics (Analgesic Drugs)IBA 02/2020 - 01/2012
2	Pentylenetetrazole (Metrazol)IBA 01/2017 - 08/2014
2	Tiagabine (Gabitril)FDA Link 06/2013 - 01/2012
1	Chemical Warfare AgentsIBA 01/2024
1	InsecticidesIBA 01/2024
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2023
1	Amyloid (Amyloid Fibrils)IBA 12/2023
1	LigandsIBA 12/2023
1	Scopolamine (Hyoscine)FDA Link 12/2023
1	ButyrylcholinesteraseIBA 12/2023
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2021
1	Streptozocin (Streptozotocin)FDA Link 01/2021
1	AldehydesIBA 11/2020
1	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 11/2020
1	Serine (L-Serine)FDA Link 02/2020
1	Membrane Transport Proteins (Biological Pump)IBA 02/2020
1	Cholinergic ReceptorsIBA 09/2018
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 09/2018
1	EsterasesIBA 09/2018
1	Pilocarpine (Ocusert)FDA LinkGeneric 01/2017
1	hydrazine (hydrazine dihydrochloride)IBA 02/2015
1	compound 18IBA 01/2012
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2012
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2012

Therapy/Procedure

2	Therapeutics 01/2021 - 06/2013
2	Drug Therapy (Chemotherapy) 01/2021 - 09/2018